Tests to assess motor phenotype in mice: a user's guide
Identifieur interne : 000295 ( Main/Exploration ); précédent : 000294; suivant : 000296Tests to assess motor phenotype in mice: a user's guide
Auteurs : Simon P. Brooks [Royaume-Uni] ; Stephen B. Dunnett [Royaume-Uni]Source :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2009-07.
Abstract
The characterization of mouse models of human disease is essential for understanding the underlying pathophysiology and developing new therapeutics. Many diseases are often associated with more than one model, and so there is a need to determine which model most closely represents the disease state or is most suited to the therapeutic approach under investigation. In the case of neurological disease, motor tests provide a good read-out of neurological function. This overview of available motor tasks aims to aid researchers in making the correct choice of test when attempting to tease out a transgenic phenotype or when assessing the recovery of motor function following therapeutic intervention.
Url:
DOI: 10.1038/nrn2652
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000397
- to stream Istex, to step Curation: 000241
- to stream Istex, to step Checkpoint: 000092
- to stream Main, to step Merge: 000296
- to stream Main, to step Curation: 000295
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tests to assess motor phenotype in mice: a user's guide</title><author><name sortKey="Brooks, Simon P" sort="Brooks, Simon P" uniqKey="Brooks S" first="Simon P." last="Brooks">Simon P. Brooks</name></author><author><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:038254830D14BE632FEA5A2F185939B08D995718</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1038/nrn2652</idno><idno type="url">https://api.istex.fr/document/038254830D14BE632FEA5A2F185939B08D995718/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000397</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000397</idno><idno type="wicri:Area/Istex/Curation">000241</idno><idno type="wicri:Area/Istex/Checkpoint">000092</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000092</idno><idno type="wicri:doubleKey">1471-003X:2009:Brooks S:tests:to:assess</idno><idno type="wicri:Area/Main/Merge">000296</idno><idno type="wicri:Area/Main/Curation">000295</idno><idno type="wicri:Area/Main/Exploration">000295</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Tests to assess motor phenotype in mice: a user's guide</title><author><name sortKey="Brooks, Simon P" sort="Brooks, Simon P" uniqKey="Brooks S" first="Simon P." last="Brooks">Simon P. Brooks</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, South Wales, CF10 3AX</wicri:regionArea><wicri:noRegion>CF10 3AX</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, South Wales, CF10 3AX</wicri:regionArea><wicri:noRegion>CF10 3AX</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Neuroscience</title><idno type="ISSN">1471-003X</idno><idno type="eISSN">1471-0048</idno><imprint><publisher>Nature Publishing Group</publisher><date type="published" when="2009-07">2009-07</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="519">519</biblScope><biblScope unit="page" to="529">529</biblScope></imprint><idno type="ISSN">1471-003X</idno></series><idno type="istex">038254830D14BE632FEA5A2F185939B08D995718</idno><idno type="DOI">10.1038/nrn2652</idno><idno type="ArticleID">nrn2652</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1471-003X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The characterization of mouse models of human disease is essential for understanding the underlying pathophysiology and developing new therapeutics. Many diseases are often associated with more than one model, and so there is a need to determine which model most closely represents the disease state or is most suited to the therapeutic approach under investigation. In the case of neurological disease, motor tests provide a good read-out of neurological function. This overview of available motor tasks aims to aid researchers in making the correct choice of test when attempting to tease out a transgenic phenotype or when assessing the recovery of motor function following therapeutic intervention.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Brooks, Simon P" sort="Brooks, Simon P" uniqKey="Brooks S" first="Simon P." last="Brooks">Simon P. Brooks</name></noRegion><name sortKey="Brooks, Simon P" sort="Brooks, Simon P" uniqKey="Brooks S" first="Simon P." last="Brooks">Simon P. Brooks</name><name sortKey="Brooks, Simon P" sort="Brooks, Simon P" uniqKey="Brooks S" first="Simon P." last="Brooks">Simon P. Brooks</name><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name><name sortKey="Dunnett, Stephen B" sort="Dunnett, Stephen B" uniqKey="Dunnett S" first="Stephen B." last="Dunnett">Stephen B. Dunnett</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000295 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000295 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= DanceTherParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:038254830D14BE632FEA5A2F185939B08D995718
|texte= Tests to assess motor phenotype in mice: a user's guide
}}
| This area was generated with Dilib version V0.6.35. |  |